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Alpha-lipoic acid (ALA) is a versatile compound that plays a key role in energy production and acts as an important antioxidant in the body. It exists in two forms: as R-alpha-lipoic acid (R-ALA) and S-alpha-lipoic acid (S-ALA). R-ALA is the natural and more biologically active form, while S-ALA is less bioavailable.
Quality products with alpha lipoic acid (ALA) usually contain a mixture of both forms with the highest possible proportion of R-ALA compared to S-ALA. R-ALA offers superior stability and bioavailability compared to S-ALA. It is easily absorbed by the body and is readily available for various biological processes.
R-ALA is known for its ability to help neutralize harmful free radicals and protect against oxidative damage. Another important advantage of R-ALA is its ability to regenerate other antioxidants , such as vitamins C and E , glutathione and coenzyme Q10 .
This unique property makes R-ALA a valuable asset in maintaining a well-functioning antioxidant defense system. In addition, R-ALA has been studied for its potential benefits in controlling blood sugar and insulin sensitivity . It can help increase glucose uptake by cells, improve insulin signaling and promote healthy blood sugar levels . These abilities make R-ALA a promising supplement for individuals with metabolic conditions such as diabetes or prediabetes . In addition to its antioxidant and metabolic benefits, R-ALA shows promising anti-inflammatory abilities by inhibiting the activation of pro-inflammatory signaling pathways.
There are also supplements with only R-ALA , in addition they contain a stabilized form called Na-R-ALA (sodium salt of R-alpha-lipoic acid). Na-R-ALA has increased stability and solubility in water, resulting in better absorption and utilization by the body. A form of R-ALA and Na-R-ALA has shown promise in supporting nerve health . It can help protect nerves from damage and promote nerve regeneration .
In addition, ALA has been investigated for its potential role in skin health . It can help protect skin from UV damage , reduce signs of aging and promote healthy skin . The antioxidant and anti-inflammatory properties of ALA contribute to its positive effects on skin health.